Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests
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چکیده
منابع مشابه
the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
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15 صفحه اولPredicting drug pharmacokinetics in humans from in vitro metabolism studies.
The pharmaceutical industry is committed to market safer drugs with fewer side effects, predictable pharmacokinetic properties and quantifiable drug-drug interactions. There is an increasing need to develop robust, enhanced-throughput in vitro assays, which accurately extrapolate to humans. The major drug metabolizing human hepatic cytochrome P450s (CYPs; CYP1A2, 2C9, 2C19, 2D6 and 3A4) have be...
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Nonimmediate drug hypersensitivity reactions (DHRs) are diffi cult to manage in daily clinical practice, mainly owing to their heterogeneous clinical manifestations and the lack of selective biological markers. In vitro methods are necessary to establish a diagnosis, especially given the low sensitivity of skin tests and the inherent risks of drug provocation testing. In vitro evaluation of non...
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Concentrations of ethanol similar to those in the blood of intoxicated patients suppressed phytohemagglutinin- or streptolysin O-induced lymphocyte transformation, and inhibited bone marrow granulocyte colony growth in soft agar. Inhibition of lymphocyte transformation and granulocyte colony growth occurred despite the presence of large concentrations of folate and other vitamins. These in vitr...
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When drugs are given in combination, which is common practice in adjuvant breast cancer treatment, interactions can occur that alter an agent’s pharmacokinetics (PKs) and pharmacodynamics (PDs) and potentiate the toxicity of the anti-cancer therapies. This is especially true for drugs that are substrates or inhibitors of P-glycoprotein (PGP), including docetaxel (DOCETAXEL), doxorubicinorubicin...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1998
ISSN: 0923-7534
DOI: 10.1023/a:1008245906772